Aortic regurgitation
affects over 2.7 million
people in the U.S.1
Many live with AR for years before symptoms appear—
with the heart working harder than it should.
Over time, this added strain can weaken the heart and lead to symptoms, including the following:
Fatigue or Weakness
Feeling unusually tired or drained, even after
small amounts of activity, may be a sign that
your heart is working harder than it should.
Shortness of Breath
Difficulty catching your breath during daily
activities or while lying down can be linked
to worsening AR.
Rapid Heartbeat
A fluttering or rapid heartbeat may occur as
your heart compensates for the backflow of
blood caused by AR.
Swelling in Ankles or Feet
Fluid buildup in the legs, ankles, or feet can
happen if AR progresses.
Eventually, AR will cause heart failure
and, if left untreated, can
lead to death2
Experience any of
these symptoms?
Find out if you're eligible to participate in
the ARTIST Trial.
The ARTIST Trial is the first study of
its kind to compare two treatment
options for patients with AR
Surgical aortic valve replacement (SAVR)
SAVR is a recommended treatment for aortic regurgitation. It involves opening the chest and using a heart-lung machine to temporarily take over the function of the heart while a surgeon replaces the damaged valve with a new one. Surgical valve replacement is an approved and proven treatment for patients with severe AR.
Transcatheter aortic valve replacement (TAVR)
TAVR is a less invasive option to replace the aortic valve. During the procedure, a thin tube, called a catheter, is inserted through the groin and guided to the heart. A replacement valve is then delivered through the catheter and placed inside the heart. Once the valve is in place, the catheter is removed and the incision is closed. Doctors are studying whether TAVR is a good option for patients with severe aortic regurgitation.
Wondering if this trial
might be right for you?
Take a quick 1–2 minute survey. If you qualify, a study
team member will reach out to walk you through the
next steps.
Who may qualify for this
clinical trial?
You have moderate-to-severe or
severe aortic regurgitation (AR)
Confirmed by heart imaging tests like an echocardiogram or cardiac MRI.
Your AR is causing symptoms
that affect your daily life
Such as shortness of breath, fatigue, or other signs of heart strain.
You’re willing to return for
follow-up visits
To make sure everything is going well after your procedure.
